Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In Vivo

19 Dec 2011

Abstract excerpt

Methionine S-adenosyltransferase (MAT) catalyzes the only reaction that produces the major methyl donor in mammals. Low-dose methotrexate is the most commonly used disease-modifying antirheumatic drug in human rheumatic conditions. The present study was conducted to test the hypothesis that methotrexate inhibits MAT expression and activity in vitro and in vivo. HepG2 cells were cultured under folate restriction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Biochemical and Molecular Research
Share to Folate and B Vitamins Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22193356
DOI: 10.2119/molmed.2011.00048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In VivoPMID 22193356Read ↗

Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapySemantic proximity Read ↗

5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion.Semantic proximity Read ↗

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.Semantic proximity Read ↗

Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.Semantic proximity Read ↗

Molecular genetics of hepatic methionine adenosyltransferase deficiency.Semantic proximity Read ↗

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.Semantic proximity Read ↗

Molecular mechanisms of an inborn error of methionine pathway. Methionine adenosyltransferase deficiency.Semantic proximity Read ↗

Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.Semantic proximity Read ↗

Structural and functional studies of human methionine adenosyltransferasesSemantic proximity Read ↗

Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protect de Novo Thymidylate Biosynthesis during Folate DeficiencySemantic proximity Read ↗

MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblastsSemantic proximity Read ↗

Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.