Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

14 Dec 2011

Abstract excerpt

OBJECTIVE: Global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts (RASFs) contributes to their intrinsic activation. The aim of this study was to investigate whether increased polyamine metabolism is associated with a decreased level of S-adenosyl methionine (SAM), causing global DNA hypomethylation. METHODS: Synovial fibroblasts were isolated from synovial tissue obtained from 12 patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Folate and B Vitamins Research
Share to Polyamine Metabolism and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22170508
DOI: 10.1002/art.34340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblastsPMID 22170508Read ↗

Epigenetics in rheumatoid arthritisSemantic proximity Read ↗

MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblastsSemantic proximity Read ↗

Positive Regulation of S-adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation FactorsSemantic proximity Read ↗

Abnormal DNA methylation pattern and expression of DNA methyltransferase 1 promote synovitis and bone destruction in rheumatoid arthritisSemantic proximity Read ↗

Regulation of DNA Methylation in Rheumatoid Arthritis SynoviocytesSemantic proximity Read ↗

Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast‐like SynoviocytesSemantic proximity Read ↗

The role of histone deacetylases in rheumatoid arthritis fibroblast-like synoviocytesSemantic proximity Read ↗

Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patientsSemantic proximity Read ↗

Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblastsSemantic proximity Read ↗

Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In VivoSemantic proximity Read ↗

Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.