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Article

MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblasts

1 Oct 2016

Abstract excerpt

BACKGROUND: The DNA of rheumatoid arthritis synovial fibroblasts (RASF) is globally hypomethylated; this contributes to an aggressive behaviour. In an attempt to remethylate these cells, we supplemented with methyl donors. We investigated the possible interference of microRNAs (miRs). MATERIAL AND METHODS: RASF were treated with L-methionine or betaine. Transcripts of de novo methyltransferases (DNMTs) and miRs...

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PMID: 27843576
DOI: 10.1136/rmdopen-2016-000299

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