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Article

Systematic immunohistochemistry screening for Lynch syndrome in early age-of-onset colorectal cancer patients undergoing surgical resection.

Journal of the American College of Surgeons - 1 Jan 2012

Steinhagen Emily, Shia Jinru, Markowitz Arnold J, Stadler Zsofia K, Salo-Mullen Erin E, Zheng Junting, Lee-Kong Steven A, Nash Garrett M, Offit Kenneth, Guillem José G

Abstract excerpt

BACKGROUND: Lynch syndrome (LS), defined by a deleterious (pathogenic) germline mutation in a mismatch repair (MMR) gene, is characterized by early age-of-onset colorectal cancer (CRC). Because clinical criteria for LS, such as the Amsterdam II Criteria, may miss cases, reflex tumor tissue testing of all CRC patients for LS has been proposed. Our study describes the impact of routine immunohistochemistry (IHC)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22192923
DOI: 10.1016/j.jamcollsurg.2011.10.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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