Article
Prospective immunohistochemical analysis of primary colorectal cancers for loss of mismatch repair protein expression.
Clinical colorectal cancer - 1 Oct 2010
Lee-Kong Steven A, Markowitz Arnold J, Glogowski Emily, Papadopoulos Christopher, Stadler Zsofia, Weiser Martin R, Temple Larissa K, Guillem José G
Abstract excerpt
BACKGROUND: Evaluation of patients for Lynch syndrome includes assessment of age and family cancer history as well as testing for microsatellite instability and alterations in mismatch repair (MMR) genes. We examined the value of routine immunohistochemistry (IHC) for MMR proteins in patients with colorectal cancer (CRC) undergoing resection at a single institution. PATIENTS AND METHODS: Beginning in July 2006,...
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