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Article

Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2012

Green Danielle E, Adler Benjamin J, Chan Meilin E, Rubin Clinton T

Abstract excerpt

Stem cell depletion and compromised bone marrow resulting from radiation exposure fosters long-term deterioration of numerous physiologic systems, with the degradation of the skeletal system ultimately increasing the risk of fractures. To study the interrelationship of damaged bone marrow cell populations with trabecular microarchitecture, 8- and 16-week-old C57BL/6 male mice were sublethally irradiated with 5 Gy...

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PMID: 22190044
DOI: 10.1002/jbmr.1505

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