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Article

Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration.

Stem cell research - 1 Sept 2014

Blaber E A, Dvorochkin N, Torres M L, Yousuf R, Burns B P, Globus R K, Almeida E A C

Abstract excerpt

Mechanical loading of mammalian tissues is a potent promoter of tissue growth and regeneration, whilst unloading in microgravity can cause reduced tissue regeneration, possibly through effects on stem cell tissue progenitors. To test the specific hypothesis that mechanical unloading alters differentiation of bone marrow mesenchymal and hematopoietic stem cell lineages, we studied cellular and molecular aspects of...

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Source

Identifiers

PMID: 25011075
DOI: 10.1016/j.scr.2014.05.005

Genes

CSF2
FUT1
GDF15
PTPRC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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