Article

Rare by Natural Selection: Tunable Disulfide-bonded Supramolecular Antimicrobials Peptides

2021-06-09

Abstract excerpt

<title>Abstract</title> <p>Short helical antimicrobial peptides forming inter-molecular disulfide bonds are selected against in nature, and were utilized here to design switchable antimicrobials via the formation of functional supramolecular fibrils. Specifically, using the available structural information on the stable fibril-forming human LL-37(17-29), we designed cysteine mutations and demonstrated position-de...

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Literature Corpus work: de2bad98-115b-5304-8e1a-daa2400b80b5
DOI: 10.21203/rs.3.rs-578319/v1

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