Article
Comparison of oxidative stress and the frequency of polymorphisms in the HFE gene between hemoglobin S trait blood donors and sickle cell disease patients.
Genetics and molecular research : GMR - 8 Dec 2011
Viana-Baracioli L M S, Tukamoto Junior N C, Ricci Junior O, Mattos L C, Ângulo I L, Bonini-Domingos C R
Abstract excerpt
It is well documented that Hb S and iron affect blood cells, and trigger oxidative processes and generation of free radicals with potential for lipid peroxidation. We evaluated the frequency of polymorphisms in the HFE gene in Hb AS blood donors and how these polymorphisms influenced lipid peroxidation and antioxidant capacity. Blood samples were collected from 211 Hb AS blood donors, 119 Hb AA blood donors...
Topics
- Adolescent
- Adult
- Aged
- Analysis of Variance
- Antioxidants
- Blood Donors
- Child
- Chromans
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Hemochromatosis Protein
- Hemoglobin, Sickle