Article
Effect of Hereditary Hemochromatosis Gene H63D and C282Y Mutations on Iron Overload in Sickle Cell Disease Patients.
Turkish journal of haematology : official journal of Turkish Society of Haematology - 1 Dec 2016
Terzi Yunus Kasım, Bulakbaşı Balcı Tuğçe, Boğa Can, Koç Zafer, Yılmaz Çelik Zerrin, Özdoğu Hakan, Karakuş Sema, Şahin Feride İffet
Abstract excerpt
OBJECTIVE: Hemochromatosis is an autosomal recessive disease that is one of the most important reasons for iron overload. Sickle cell disease is a hemoglobinopathy that occurs as a result of a homozygous mutation in the hemoglobin gene. Erythrocyte transfusion is frequently used in the treatment of this disease. Iron overload as a result of transfusion is important in the mortality and morbidity of sickle cell...
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