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Article

Neuroprotective Effect of Protaetia brevitarsis seulensis' Water Extract on Trimethyltin-Induced Seizures and Hippocampal Neurodegeneration.

International journal of molecular sciences - 12 Jan 2021

Lee Sueun, Seo Young Hye, Song Jun Ho, Kim Wook Jin, Lee Ji Hye, Moon Byeong Cheol, Ang Mary Jasmin, Kim Sung Ho, Moon Changjong, Lee Jun, Kim Joong Sun

Abstract excerpt

This study aimed to investigate whether the Protaetia brevitarsis seulensis (PB)' water extract (PBWE) ameliorates trimethyltin (TMT)-induced seizures and hippocampal neurodegeneration. To investigate the potential neuroprotective effect of the PBWE in vitro, a lactate dehydrogenase (LDH) assay was conducted in TMT-treated primary cultures of mouse hippocampal neurons. In TMT-treated adult C57BL/6 mice,...

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PMID: 33445535
DOI: 10.3390/ijms22020679
PMCID: PMC7827571

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