Article
Molecular Mechanisms of Lupus Susceptibility Allele PBX1D.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2023
Park Yuk Pheel, Roach Tracoyia, Soh Sujung, Zeumer-Spataro Leilani, Choi Seung-Chul, Ostrov David A, Yang Young, Morel Laurence
Abstract excerpt
Pre-B cell leukemia homeobox 1 (PBX1) controls chromatin accessibility to a large number of genes in various cell types. Its dominant negative splice isoform, PBX1D, which lacks the DNA and Hox-binding domains, is expressed more frequently in the CD4+ T cells from lupus-prone mice and patients with systemic lupus erythematosus than healthy control subjects. PBX1D overexpression in CD4+ T cells impaired regulatory...
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