Impact of immunogenetic IL28B polymorphism on natural outcome of HCV infection.

doi:10.1155/2014/710642

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Article

Impact of immunogenetic IL28B polymorphism on natural outcome of HCV infection.

BioMed research international - 1 Jan 2014

De Re Valli, Gragnani Laura, Fognani Elisa, Piluso Alessia, Izzo Francesco, Mangia Alessandra, Crovatto Marina, Gava Graziella, Casarin Pietro, Sansonno Domenico, Racanelli Vito, De Vita Salvatore, Pioltelli Pietro, Caggiari Laura, De Zorzi Mariangela, Berretta Massimiliano, Gini Andrea, Zucchetto Antonella, Buonaguro Franco Maria, De Paoli Paolo, Zignego Anna Linda

Abstract excerpt

With the aim of investigating whether interleukin 28B gene (IL28B) rs1297860 polymorphism is associated with different hepatitis C (HCV) infection statuses, we compared IL28B allelic distribution in an Italian case series of 1050 patients with chronic infection and different outcomes, 47 individuals who spontaneously cleared HCV, and 178 blood donors. Furthermore, we compared IL28B variants among 3882 Caucasian...

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Identifiers

PMID: 24707497
DOI: 10.1155/2014/710642
PMCID: PMC3955679

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