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Article

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.

Nature cell biology - 18 Dec 2011

Austgen Kathryn, Johnson Emily T, Park Tae-Ju, Curran Tom, Oakes Scott A

Abstract excerpt

Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration. The signals communicating catastrophic ER damage to the mitochondrial apoptotic machinery remain poorly understood. We used a biochemical approach to purify a cytosolic activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22179045
DOI: 10.1038/ncb2395
PMCID: PMC3245775

Genes

CRK
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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