Article
The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion.
Cell death & disease - 13 Feb 2014
Garg M, Ramdas N, Vijayalakshmi M, Shivashankar G V, Sarin A
Abstract excerpt
The loss of mitochondrial integrity as a consequence of apoptogenic complexes formed on the outer membrane constitutes a key step in controlling progression of apoptotic cascades. Here, we show that multiple members of the linker histone (LH) family of proteins modify apoptotic cascades initiated by the Bcl-2 protein Bak, and impart resistance to its endogenous antagonist Bcl-xL. Our experiments reveal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.