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Article

STAT3 in Breast Cancer Onset and Progression: A Matter of Time and Context

18 Sept 2018

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is responsible for mediating the transcriptional programs downstream of several cytokine, growth factor, and oncogenic stimuli. Its expression and activity are consistently linked to cellular transformation, as well as tumor initiation and progression. Due to this central role, STAT3 is widely considered a good target for anti-cancer therapy; however, the...

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PMID: 30231553
DOI: 10.3390/ijms19092818

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