Article
Upregulation of soluble and membrane-bound human leukocyte antigen G expression is primarily observed in the milder histopathological stages of chronic hepatitis C virus infection.
Human immunology - 1 Mar 2012
de Oliveira Crispim Janaina Cristiana, Silva Tarsia Giabardo Alves, Souto Francisco José Dutra, Souza Fernanda Fernandes, Bassi Carmen Lucia, Soares Christiane Pienna, Zucoloto Sérgio, Moreau Philippe, Martinelli Ana de Lourdes Candolo, Donadi Eduardo Antonio
Abstract excerpt
Chronic hepatitis C virus (HCV) infection is a worldwide health problem that may evolve to cirrhosis and hepatocellular carcinoma. Incompletely understood immune system mechanisms have been associated with impaired viral clearance. The nonclassical class I human leukocyte antigen G (HLA-G) molecule may downregulate immune system cell functions exhibiting well-recognized tolerogenic properties. HCV genotype was...
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