Article
HLA-G regulatory polymorphisms are associated with susceptibility to HCV infection.
HLA - 1 Mar 2017
Catamo E, Zupin L, Freato N, Polesello V, Celsi F, Crocè S L, Masutti F, Pozzato G, Segat L, Crovella S
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) is able to bypass the immune system modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell production. Because the human leukocyte antigen (HLA)-G molecule has immunomodulatory properties inhibiting the function and production of natural killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 toward Th2 response, we hypothesized...
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