Article
HLA-G liver expression in chronically HIV/hepatitis C-coinfected individuals.
Annals of hepatology - 1 Jan 2025
Vilar Fernando Crivelenti, Donadi Eduardo, da Fonseca Benedito Antônio Lopes, Freitas Janaina Cristiana de Oliveira Crispim, Borducchi Ana Letícia Gomide Zanin, Santana Rodrigo de Carvalho
Abstract excerpt
INTRODUCTION AND OBJECTIVES: Hepatitis C-induced liver disease represents a significant threat to the survival of people living with HIV. HIV/HCV-coinfected individuals have a more rapid progression to cirrhosis and its complications than HCV monoinfected patients. Although the underlying mechanisms remain unclear, HLA-G, a non-classical class I HLA molecule, has a well-recognized property to down-regulate the...
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