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Article

Non-classical MHC-I human leukocyte antigen (HLA-G) in hepatotropic viral infections and in hepatocellular carcinoma.

Human immunology - 1 Dec 2014

Catamo Eulalia, Zupin Luisa, Crovella Sergio, Celsi Fulvio, Segat Ludovica

Abstract excerpt

The human leukocyte antigen (HLA)-G is a "nonclassical" major histocompatibility complex (MHC) class Ib gene, located at chromosome 6, in the 6p21.3 region. The HLA-G presents immunomodulatory functions essential in pregnancy for the tolerance of the semi-allogenic fetus, but an abnormal expression of HLA-G has been observed in numerous pathological conditions, such as tumors, autoimmune diseases and viral...

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Identifiers

PMID: 25318079
DOI: 10.1016/j.humimm.2014.09.019

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