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Article

HLA-E gene polymorphisms in chronic hepatitis C: Impact on HLA-E liver expression and disease severity.

Human immunology - 1 Mar 2021

Araújo Roberta Chaves, Bertol Bruna Cristina, César Dias Fabricio, Debortoli Guilherme, Almeida Patrícia Holanda, Fernandes Souza Fernanda, Villanova Marcia Guimarães, Ramalho Leandra Naira Zambelli, Candolo Martinelli Ana Lourdes, Cruz Castelli Érick da, Mendes Junior Celso Teixeira, Antonio Donadi Eduardo

Abstract excerpt

Hepatitis C virus usually produces chronic infection and liver damage. Considering that: i) the human leukocyte antigen-E (HLA-E) molecule may modulate the immune response, and ii) little is known about the role of HLA-E gene variability on chronic hepatitis C, we studied the impact of HLA-E polymorphisms on the magnitude of HLA-E liver expression and severity of hepatitis C. HLA-E variability was evaluated in...

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Identifiers

PMID: 33597096
DOI: 10.1016/j.humimm.2021.01.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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