Article
[KRAS and epidermal growth factor receptor gene mutation in non-small cell lung cancer].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases - 1 Sept 2011
Hu Wei, Hu Yi, Zhou Kun, Wang Yue-bin, Xia Zong-jiang
Abstract excerpt
OBJECTIVE: To study KRAS and epidermal growth factor receptor (EGFR) mutations in primary non-small cell lung cancer (NSCLC) and their association with the effects of targeted therapy. METHODS: Gene mutations of KRAS and EGFR in both primary tumors and local lymph node metastases from 150 patients with NSCLC were analyzed by direct sequencing. Twelve of the patients were given gefitinib as neoadjuvant therapy...
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