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Reversed mutation rates of KRAS and EGFR genes in adenocarcinoma of the lung in Taiwan and their implications.

Cancer - 1 Dec 2008

Wu Chun-Chieh, Hsu Hui-Yu, Liu Hui-Ping, Chang John Wen-Cheng, Chen Ya-Ting, Hsieh Wen-Yu, Hsieh Jia-Juan, Hsieh Meng-Shu, Chen Yi-Rong, Huang Shiu-Feng

Abstract excerpt

BACKGROUND: In western countries, the Kirsten ras oncogene homolog gene (KRAS) mutation rate is high in patients with nonsmall cell lung cancer (NSCLC), especially in those with adenocarcinoma (30%-50%), but the epidermal growth factor receptor gene (EGFR) mutation rate is very low (3%-8%). In addition, KRAS mutations reportedly were associated with EGFR tyrosine kinase inhibitor (EGFR-TKI) resistance. In Taiwan,...

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Source

Identifiers

PMID: 18932251
DOI: 10.1002/cncr.23925

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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