Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.

Journal of cell science - 15 Apr 2005

Vanegas Maria, Llano Manuel, Delgado Sharon, Thompson Daniah, Peretz Mary, Poeschla Eric

Abstract excerpt

To investigate the basis for the LEDGF/p75 dependence of HIV-1 integrase (IN) nuclear localization and chromatin association, we used cell lines made stably deficient in endogenous LEDGF/p75 by RNAi to analyze determinants of its location in cells and its ability to interact with IN. Deletion of C-terminal LEDGF/p75 residues 340-417 preserved nuclear and chromatin localization but abolished the interaction with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Avian Leukosis Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Regulator

Share to HIV Integrase

Share to NIH 3T3 Cells

Share to Nuclear Localization Signals

Share to Vero Cells

Share to Virus Integration

Source

Identifiers

PMID: 15797927
DOI: 10.1242/jcs.02299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.PMID 15797927Read ↗

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.Semantic proximity Read ↗

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Semantic proximity Read ↗

Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 IntegraseSemantic proximity Read ↗

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA IntegrationSemantic proximity Read ↗

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug DiscoverySemantic proximity Read ↗

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human CellsSemantic proximity Read ↗

An Essential Role for LEDGF/p75 in HIV IntegrationSemantic proximity Read ↗

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1ReplicationSemantic proximity Read ↗

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 IntegraseSemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

LEDGF Dominant Interference Proteins Demonstrate Prenuclear Exposure of HIV-1 Integrase and Synergize with LEDGF Depletion To Destroy Viral InfectivitySemantic proximity Read ↗

Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.