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Article

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.

The Journal of biological chemistry - 29 Aug 2003

Maertens Goedele, Cherepanov Peter, Pluymers Wim, Busschots Katrien, De Clercq Erik, Debyser Zeger, Engelborghs Yves

Abstract excerpt

We have reported that human immunodeficiency virus type 1 (HIV-1) integrase (IN) forms a specific nuclear complex with human lens epithelium-derived growth factor/transcription co-activator p75 (LEDGF/p75) protein. We now studied the IN-LEDGF/p75 interaction and nuclear import of IN in living cells using fusions of IN and LEDGF/p75 with enhanced green fluorescent protein and far-red fluorescent protein HcRed1. We...

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Share to Active Transport, Cell Nucleus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Indirect

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Share to Intercellular Signaling Peptides and Proteins

Share to Microscopy, Confocal

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Source

Identifiers

PMID: 12796494
DOI: 10.1074/jbc.M303594200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.PMID 12796494Read ↗

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.Semantic proximity Read ↗

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human CellsSemantic proximity Read ↗

Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 IntegraseSemantic proximity Read ↗

An Essential Role for LEDGF/p75 in HIV IntegrationSemantic proximity Read ↗

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA IntegrationSemantic proximity Read ↗

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug DiscoverySemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Semantic proximity Read ↗

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1ReplicationSemantic proximity Read ↗

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus ReplicationSemantic proximity Read ↗

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 IntegraseSemantic proximity Read ↗

Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75Semantic proximity Read ↗

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