Article
Predicting the effects of copy-number variation in double and triple mutant combinations.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2012
Carter Gregory W, Hays Michelle, Li Song, Galitski Timothy
Abstract excerpt
The study of genetic interactions is a powerful tool in inferring structure and function of biological networks. To date, genetic interaction studies have been dominated by pair-wise gene deletion screens. However, classical genetic analysis and natural genetic variation involve diverse gene forms ranging from null alleles to copy number variants. Moreover, genetic variation is typically multifactorial....
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