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Article

Semaphorin 3fa Controls Ocular Vascularization From the Embryo Through to the Adult.

Investigative ophthalmology & visual science - 1 Feb 2021

Halabi Rami, Watterston Charlene, Hehr Carrie Lynn, Mori-Kreiner Risa, Childs Sarah J, McFarlane Sarah

Abstract excerpt

Purpose: Pathological blood vessel growth in the eye is implicated in several diseases that result in vision loss, including age-related macular degeneration and diabetic retinopathy. The limits of current disease therapies have created the need to identify and characterize new antiangiogenic drugs. Here, we identify the secreted chemorepellent semaphorin-3fa (Sema3fa) as an endogenous anti-angiogenic in the eye....

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Source

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Identifiers

PMID: 33595613
DOI: 10.1167/iovs.62.2.21
PMCID: PMC7900886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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