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The Primary Occurrence of<i>BRAF<sup>V600E</sup></i>Is a Rare Clonal Event in Papillary Thyroid Carcinoma

15 Dec 2011

Abstract excerpt

CONTEXT: BRAF(V600E) is considered a primary event, a negative prognostic marker, and a site for pharmacological intervention in papillary thyroid carcinoma (PTC). We asked whether BRAF(V600E) can occur as a subclonal event in PTC and whether this and other oncogenes can coexist in the same tumor. STUDY DESIGN: We determined by pyrosequencing the percentage of mutant BRAF, NRAS, and KRAS alleles in a series of...

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Identifiers

PMID: 22170714
DOI: 10.1210/jc.2011-0618

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The Primary Occurrence of<i>BRAF<sup>V600E</sup></i>Is a Rare Clonal Event in Papillary Thyroid CarcinomaPMID 22170714Read ↗

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