Article
Allele percentage of the BRAF V600E mutation in papillary thyroid carcinomas and corresponding lymph node metastases: no evidence for a role in tumor progression.
The Journal of clinical endocrinology and metabolism - 1 May 2013
Gandolfi Greta, Sancisi Valentina, Torricelli Federica, Ragazzi Moira, Frasoldati Andrea, Piana Simonetta, Ciarrocchi Alessia
Abstract excerpt
CONTEXT: The relevance of the BRAF V600E mutation in papillary thyroid carcinoma (PTC) as a negative prognostic factor is a subject of intense debate. This mutation has been associated with several clinicopathological features, but the lack of consistency among data does not support its usefulness as marker of tumor aggressiveness and poorer outcome. Due to the genetic heterogeneity of the tumor, both the...
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