Article
Quantification of BRAF V600E alleles predicts papillary thyroid cancer progression.
Endocrine-related cancer - 1 Jan 2014
Kim Min-Hee, Bae Ja Seong, Lim Dong-Jun, Lee Hyoungnam, Jeon So Ra, Park Gyeong Sin, Jung Chan Kwon
Abstract excerpt
The BRAF V600E mutation is the most common genetic alteration in thyroid cancer. However, its clinicopathological significance and clonal mutation frequency remain unclear. To clarify the inconsistent results, we investigated the association between the allelic frequency of BRAF V600E and the clinicopathological features of classic papillary thyroid carcinoma (PTC). Tumour tissues from two independent sets of...
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