BRAF V600E Mutation and Papillary Thyroid Cancer: Chicken or Egg?

Abstract excerpt

The BRAFV600E mutation, resulting from a T1799A transversion nucleotide change in the BRAF gene, was discovered in papillary thyroid cancer (PTC) initially in 2003 (1). Many other studies quickly showed that, among different thyroid cancers, this was a PTC-specific genetic event, occurring in about 45% of cases on average (2); the only other thyroid cancer in which this mutation occurs sometimes is the presumably...

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