Article
Occurrence of BRAF mutations in a Polish cohort of PTC patients - preliminary results.
Endokrynologia Polska - 1 Jan 2000
Czarniecka Agnieszka, Rusinek Dagmara, Stobiecka Ewa, Krajewska Jolanta, Kowal Monika, Kropińska Aleksandra, Zebracka Jadwiga, Kowalska Małgorzata, Włoch Jan, Maciejewski Adam, Handkiewicz-Junak Daria
Abstract excerpt
INTRODUCTION: Genetic alterations involving the mitogen-activated protein kinase (MAPK) pathway are frequently demonstrated in papillary thyroid cancer (PTC). BRAF(V600E), the most frequent mutation in adult patients, is present in approximately 50% of PTC. Most clinical studies have demonstrated an association of BRAF(V600E) mutation with aggressive clinicopathological characteristics and high tumour recurrence,...
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