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Article

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.

Bioorganic & medicinal chemistry letters - 1 Jan 2012

Zificsak Craig A, Gingrich Diane E, Breslin Henry J, Dunn Derek D, Milkiewicz Karen L, Theroff Jay P, Thieu Tho V, Underiner Ted L, Weinberg Linda R, Aimone Lisa D, Albom Mark S, Mason Jennifer L, Saville Lisa, Husten Jean, Angeles Thelma S, Finn James P, Jan Mahfuza, O'Kane Teresa M, Dobrzanski Pawel, Dorsey Bruce D

Abstract excerpt

The elaboration of a novel scaffold for the inhibition of JAK2 and FAK kinases was targeted in order to provide a dual inhibitor that could target divergent pathways for tumor cell progression.

Topics

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Chemistry, Pharmaceutical
Drug Design
Focal Adhesion Protein-Tyrosine Kinases
Inhibitory Concentration 50
Janus Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Chemical

Protein Kinase Inhibitors

Rats, Sprague-Dawley

Source

Identifiers

PMID: 22169263
DOI: 10.1016/j.bmcl.2011.11.049

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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