Article
Design, synthesis, and biological evaluation of new B-RafV600E kinase inhibitors.
Bioorganic & medicinal chemistry - 15 May 2018
Wang Peng-Fei, Zhang Yong-Jiao, Wang Dong, Hu Hui-Min, Wang Zhong-Chang, Xu Chen, Qiu Han-Yue, Zhu Hai-Liang
Abstract excerpt
The association of deregulated signal pathways with various diseases has long been a research hotspot. One of the most important signal pathways, the MAPK (mitogen-activated protein kinase) signal pathway, plays a vital role in transducing extracellular signals into vital intracellular mechanisms. While mutations on its key component Raf kinase lead to sever diseases, targeted inhibition has thereby become an...
Topics
- Antineoplastic Agents
- Apoptosis
- Benzamides
- Binding Sites
- Cell Line, Tumor
- Cell Proliferation
- Drug Design
- Enzyme Assays
- Humans
- Indazoles
- Indoles
- Ligands
- Molecular Docking Simulation
- Molecular Dynamics Simulation