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Article

Design, synthesis, and biological evaluation of new B-RafV600E kinase inhibitors.

Bioorganic & medicinal chemistry - 15 May 2018

Wang Peng-Fei, Zhang Yong-Jiao, Wang Dong, Hu Hui-Min, Wang Zhong-Chang, Xu Chen, Qiu Han-Yue, Zhu Hai-Liang

Abstract excerpt

The association of deregulated signal pathways with various diseases has long been a research hotspot. One of the most important signal pathways, the MAPK (mitogen-activated protein kinase) signal pathway, plays a vital role in transducing extracellular signals into vital intracellular mechanisms. While mutations on its key component Raf kinase lead to sever diseases, targeted inhibition has thereby become an...

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Identifiers

PMID: 29602674
DOI: 10.1016/j.bmc.2018.03.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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