Article
Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated.
European journal of human genetics : EJHG - 1 May 2012
Harinck Femme, Kluijt Irma, van Mil Saskia E, Waisfisz Quinten, van Os Theo A M, Aalfs Cora M, Wagner Anja, Olderode-Berends Maran, Sijmons Rolf H, Kuipers Ernst J, Poley Jan-Werner, Fockens Paul, Bruno Marco J
Abstract excerpt
PALB2-mutation carriers not only have an increased risk for breast cancer (BC) but also for pancreatic cancer (PC). Thus far, PALB2 mutations have been mainly found in PC patients from families affected by both PC and BC. As it is well known that the prevalence of gene mutations varies between different populations, we studied the prevalence of PALB2 mutations in a Dutch cohort of non-BRCA1/2 familial PC (FPC)...
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