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Article

Role of cancer-associated fibroblasts in breast cancer development and prognosis

1 Jan 2011

Abstract excerpt

Since Paget's "Seed and Soil" hypothesis in 1889 on cancer growth and metastasis, several studies on various solid tumors have confirmed the active role of the tumor milieu on the onset, growth and spread of neoplastic cells. Fibroblasts constitute the major components of the tumor microenvironment (stroma), and are therefore the most studied cell type. Therefore, a large amount of data has emerged showing the...

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PMID: 22161840
DOI: 10.1387/ijdb.113362aa

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