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Article

A single-nucleotide polymorphism in the fetal catechol-O-methyltransferase gene is associated with spontaneous preterm birth in African Americans.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2012

Thota Chandrasekhar, Menon Ramkumar, Wentz Melissa J, Fortunato Stephen J, Bartlett Jackie, Drobek Cayce O, Nair Sangeeta, Al-Hendy Ayman

Abstract excerpt

Catechol-O-methyltransferase (COMT) activity has been reported to be higher in African Americans (AA) than Caucasians (Cau). COMT converts 2- and 4-hydroxy (OH) estrogens to 2- and 4-methoxyestrogens, respectively, and can increase estrogenic milieu locally in tissues. To assess whether the increased incidence of preterm birth (PTB) among AA women is associated with single-nucleotide polymorphism (SNP) in the...

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Identifiers

PMID: 22158829
DOI: 10.1177/1933719111417885
PMCID: PMC3343133

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A single-nucleotide polymorphism in the fetal catechol-O-methyltransferase gene is associated with spontaneous preterm birth in African Americans.PMID 22158829Read ↗

Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulatorSemantic proximity Read ↗

Catechol-O-methyltransferase Gene Polymorphism (Val158Met) and Development of Pre-eclampsia.Semantic proximity Read ↗

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The COMT Val<sup>158</sup>Met Polymorphism is Significantly Associated with Early Onset Preeclampsia in Both African American and Caucasian MothersSemantic proximity Read ↗

Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.Semantic proximity Read ↗

Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17α in preeclampsia.Semantic proximity Read ↗

Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.Semantic proximity Read ↗

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.Semantic proximity Read ↗

Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.Semantic proximity Read ↗

A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).Semantic proximity Read ↗

Association between Val158Met functional polymorphism in the COMT gene and risk of preeclampsia in a Chinese population.Semantic proximity Read ↗

The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

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