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Article

Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.

PloS one - 31 Jan 2011

Hill Lori D, York Timothy P, Kusanovic Juan P, Gomez Ricardo, Eaves Lindon J, Romero Roberto, Strauss Jerome F

Abstract excerpt

Preeclampsia is a leading cause of perinatal morbidity and mortality. This disorder is thought to be multifactorial in origin, with multiple genes, environmental and social factors, contributing to disease. One proposed mechanism is placental hypoxia-driven imbalances in angiogenic and anti-angiogenic factors, causing endothelial cell dysfunction. Catechol-O-methyltransferase (Comt)-deficient pregnant mice have a...

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Source

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Identifiers

PMID: 21304959
DOI: 10.1371/journal.pone.0016681
PMCID: PMC3031618

Genes

COMT
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.PMID 21304959Read ↗

A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).Semantic proximity Read ↗

Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17α in preeclampsia.Semantic proximity Read ↗

Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.Semantic proximity Read ↗

A single-nucleotide polymorphism in the fetal catechol-O-methyltransferase gene is associated with spontaneous preterm birth in African Americans.Semantic proximity Read ↗

VAL158MET catechol O-methyltransferase polymorphism contributes to the development of preeclampsia.Semantic proximity Read ↗

Catechol-O-methyltransferase Gene Polymorphism (Val158Met) and Development of Pre-eclampsia.Semantic proximity Read ↗

The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.Semantic proximity Read ↗

Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat.Semantic proximity Read ↗

The COMT Val<sup>158</sup>Met Polymorphism is Significantly Associated with Early Onset Preeclampsia in Both African American and Caucasian MothersSemantic proximity Read ↗

The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI.Semantic proximity Read ↗

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