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Article

Mutational analysis in cytological specimens of advanced lung adenocarcinoma: a sensitive method for molecular diagnosis.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Dec 2007

Boldrini Laura, Gisfredi Silvia, Ursino Silvia, Camacci Tiziano, Baldini Editta, Melfi Franca, Fontanini Gabriella

Abstract excerpt

INTRODUCTION: The discovery that somatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with sensitivity to the EGFR tyrosine kinase inhibitors (TKIs) in lung adenocarcinomas, whereas Kras mutations are associated with resistance, has generated excitement among both clinicians and researchers studying non-small cell lung cancer (NSCLC). Mutational analysis may soon be very useful in...

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PMID: 18090579
DOI: 10.1097/JTO.0b013e31815ba1fa

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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