Article
Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes.
The oncologist - 1 Jan 2011
Lozano Maria D, Zulueta Javier J, Echeveste Jose I, Gúrpide Alfonso, Seijo Luis M, Martín-Algarra Salvador, Del Barrio Anabel, Pio Ruben, Idoate Miguel Angel, Labiano Tania, Perez-Gracia Jose Luis
Abstract excerpt
OBJECTIVE: Epidermal growth factor receptor (EGFR) and K-ras mutations guide treatment selection in non-small cell lung cancer (NSCLC) patients. Although mutation status is routinely assessed in biopsies, cytological specimens are frequently the only samples available. We determined EGFR and K-ras mutations in cytological samples. METHODS: DNA was extracted from 150 consecutive samples, including 120 Papanicolau...
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