Article
Genetic variation in ABCG1 and risk of myocardial infarction and ischemic heart disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2012
Schou Jesper, Frikke-Schmidt Ruth, Kardassis Dimitris, Thymiakou Efstathia, Nordestgaard Børge G, Jensen Gorm, Grande Peer, Tybjærg-Hansen Anne
Abstract excerpt
OBJECTIVE: ATP binding cassette transporter G1 (ABCG1) facilitates cholesterol efflux from macrophages to mature high-density lipoprotein particles. Whether genetic variation in ABCG1 affects risk of atherosclerosis in humans remains to be determined. METHODS AND RESULTS: We resequenced the core promoter and coding regions of ABCG1 in 380 individuals from the general population. Next, we genotyped 10 237...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
