Article
A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population.
Journal of human genetics - 1 Jan 2004
Shioji Keisuke, Nishioka Junko, Naraba Hiroaki, Kokubo Yoshihiro, Mannami Toshifumi, Inamoto Nozomu, Kamide Kei, Takiuchi Shin, Yoshii Masayoshi, Miwa Yoshikazu, Kawano Yuhei, Miyata Toshiyuki, Miyazaki Shunichi, Goto Yoichi, Nonogi Hiroshi, Tago Naomi, Iwai Naoharu
Abstract excerpt
To investigate the effects of polymorphisms in the ATP-binding cassette transporter A1 ( ABCA1) gene on the high-density lipoprotein cholesterol (HDL-C) level and the incidence of myocardial infarction (MI), we performed association studies. Sequence analysis identified 14 polymorphisms in the promoter region of ABCA1. After considering linkage disequilibrium, three polymorphisms in the promoter region and 11...
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