Article
c-kit gene mutation and CD117 expression in human anorectal melanomas.
Human pathology - 1 Jun 2012
Ni Shujuan, Huang Dan, Chen Xiaochen, Huang Jiaying, Kong Yunyi, Xu Ye, Du Xiang, Sheng Weiqi
Abstract excerpt
c-kit and BRAF mutations play an important role during the pathogenesis of melanoma. The subtypes of melanomas arising from different parts of the body have variable c-kit or BRAF mutation frequencies. Few studies in the literature have examined c-kit and BRAF mutation status in melanomas that occur in the anus and rectum. In this study, we analyzed 40 cases of anorectal melanoma for c-kit and BRAF mutations by...
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