Article
KIT gene mutations and copy number in melanoma subtypes.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2008
Beadling Carol, Jacobson-Dunlop Erick, Hodi F Stephen, Le Claudia, Warrick Andrea, Patterson Janice, Town Ajia, Harlow Amy, Cruz Frank, Azar Sharl, Rubin Brian P, Muller Susan, West Rob, Heinrich Michael C, Corless Christopher L
Abstract excerpt
PURPOSE: We recently identified a KIT exon 11 mutation in an anorectal melanoma of a patient who had an excellent response to treatment with imatinib. To determine the frequency of KIT mutations across melanoma subtypes, we surveyed a large series of tumors. EXPERIMENTAL DESIGN: One hundred eighty-nine melanomas were screened for mutations in KIT exons 11, 13, and 17. KIT copy number was assessed by quantitative...
Topics
- Gene Dosage
- Genes, ras
- Humans
- Melanoma
- Mutation
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins c-kit
- Skin Neoplasms