Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2011

Langer Rupert, Becker Karen, Feith Marcus, Friess Helmut, Höfler Heinz, Keller Gisela

Abstract excerpt

We present a series of 10 primary esophageal melanomas of Caucasian patients characterized clinicopathologically and on the molecular level. Mutation analysis for c-Kit (exons 9, 11, 13 and 17), PDGFR (exons 12, 14 and 18), NRAS and KRAS were determined using PCR and direct sequencing. Analysis o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Esophageal Neoplasms
Share to Germany
Share to Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Targeted Therapy

Share to Patient Selection

Share to Proto-Oncogene Proteins c-kit

Share to ras Proteins

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 21131919
DOI: 10.1038/modpathol.2010.220

Genes

BRAF
KRAS
NRAS
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21131919-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases.PMID 21131919Read ↗

Genetic mutations in primary malignant melanoma of the esophagus: case report and literature review.Semantic proximity Read ↗

Comprehensive molecular findings in primary malignant melanoma of the esophagus: A multicenter study.Semantic proximity Read ↗

Clinicopathological characteristics and mutation profiling in primary cutaneous melanoma.Semantic proximity Read ↗

Analysis of c-KIT expression and KIT gene mutation in human mucosal melanomas.Semantic proximity Read ↗

KIT genetic alterations in anorectal melanomas.Semantic proximity Read ↗

Oncogene abnormalities in a series of primary melanomas of the sinonasal tract: NRAS mutations and cyclin D1 amplification are more frequent than KIT or BRAF mutations.Semantic proximity Read ↗

Sinonasal mucosal melanoma: Molecular profile and therapeutic implications from a series of 32 cases.Semantic proximity Read ↗

Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus.Semantic proximity Read ↗

KIT Mutation Incidence and Pattern of Melanoma in Central Europe.Semantic proximity Read ↗

c-kit gene mutation and CD117 expression in human anorectal melanomas.Semantic proximity Read ↗

Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sites.Semantic proximity Read ↗

Primary malignant melanoma of the gastroesophageal junction with KIT gene exon 11 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.