Article
Identification of recurrent mutational events in anorectal melanoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2017
Yang Hui Min, Hsiao Susan J, Schaeffer David F, Lai Chi, Remotti Helen E, Horst David, Mansukhani Mahesh M, Horst Basil A
Abstract excerpt
Anorectal melanoma is a rare disease that carries a poor prognosis. To date, limited genetic analyses confirmed KIT mutations as a recurrent genetic event similar to other mucosal melanomas, occurring in up to 30% of anorectal melanomas. Importantly, a subset of tumors harboring activating KIT mutations have been found to respond to c-Kit inhibitor-based therapy, with improved patient survival at advanced tumor...
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