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Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma

19 Feb 2016

Abstract excerpt

Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has previously been shown to play a key role in the transport of RA to retinoic acid receptors (RARs) to activate their...

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PMID: 26893190
DOI: 10.1002/glia.22976

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