Article
Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.
Cellular microbiology - 1 Apr 2012
Singh Arpita, Wang Haitao, Silva Liana C, Na Chongzheng, Prieto Manuel, Futerman Anthony H, Luberto Chiara, Del Poeta Maurizio
Abstract excerpt
In previous studies we showed that the replication of Cryptococcus neoformans in the lung environment is controlled by the glucosylceramide (GlcCer) synthase gene (GCS1), which synthesizes the membrane sphingolipid GlcCer from the C9-methyl ceramide. Here, we studied the effect of the mutation of the sphingolipid C9 methyltransferase gene (SMT1), which adds a methyl group to position 9 of the sphingosine backbone...
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