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Article

Quality control of fungus-specific glucosylceramide in Cryptococcus neoformans by endoglycoceramidase-related protein 1 (EGCrP1).

The Journal of biological chemistry - 2 Jan 2012

Ishibashi Yohei, Ikeda Kazutaka, Sakaguchi Keishi, Okino Nozomu, Taguchi Ryo, Ito Makoto

Abstract excerpt

A fungus-specific glucosylceramide (GlcCer), which contains a unique sphingoid base possessing two double bonds and a methyl substitution, is essential for pathogenicity in fungi. Although the biosynthetic pathway of the GlcCer has been well elucidated, little is known about GlcCer catabolism because a GlcCer-degrading enzyme (glucocerebrosidase) has yet to be identified in fungi. We found a homologue of...

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Identifiers

PMID: 22072709
DOI: 10.1074/jbc.M111.311340
PMCID: PMC3249089

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