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Article

Role of glucuronoxylomannan and steryl glucosides in protecting against cryptococcosis.

mBio - 11 Jun 2025

Matos Gabriel Soares, Querobino Samyr M, Brauer Veronica S, Joffe Luna S, Pereira de Sa Nivea, Fernandes Caroline Mota, DaSilva Deveney, da Silva Vanessa A, Cavalcanti Neto Marinaldo Pacífico, Normile Tyler, Zhu Hengwei, Bhatia Surita R, Tan Li, Azadi Parastoo, Heiss Christian, Doering Tamara L, Del Poeta Maurizio

Abstract excerpt

The development of vaccines for fungal diseases, including cryptococcosis, is an emergent line of research and development. In previous studies, we showed that a Cryptococcus mutant lacking the SGL1 gene (∆sgl1) accumulates certain glycolipids called steryl glucosides (SGs) on the fungal capsule, promoting an effective immunostimulation that totally protects the host from a secondary cryptococcal infection....

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Share to Cryptococcosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40298449
DOI: 10.1128/mbio.00984-25
PMCID: PMC12153286

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